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+86-18088661155
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jlchongming@conminbiotech.com
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5th Floor, F8,Workshop 8, Science & Technology Incubation Park, Xinglong Comprehensive Bonded Zone, Changchun City, Jilin Province, China.
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Carbapenem Resistance Gene Detection Kit
隐藏域元素占位
Detailed introduction
"Due to the misuse of antibiotics, the detection rate of carbapenem-resistant bacteria in clinical isolates remains high. In 2024, the World Health Organization (WHO) classified carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Acinetobacter baumannii (CRAB) as among the highest-priority pathogens, while carbapenem-resistant Pseudomonas aeruginosa (CRPA) was listed as a high-priority pathogen. Therefore, using fluorescent quantitative PCR (qPCR) technology to detect resistance and perform genotyping of resistance genes enables early identification and prevention, which is of significant importance.
This kit is primarily designed based on bacterial antimicrobial susceptibility test results. It identifies and detects the five most common carbapenem-resistant genes (blaVIM, blaOXA-48, blaNDM, blaKPC, and blaIMP) in bacteria resistant to meropenem, imipenem, or ertapenem. By doing so, it helps curb the rapid spread of resistant bacteria among patients and optimizes patient management."
Product Characteristics：
Sample Type: Pure bacterial colonies.
Technology: Multiplex fluorescent quantitative PCR.
Format:Two lyophilized forms—in-situ lyophilization and microsphere lyophilization，Convenient for transportation.
Target Genes: VIM, OXA-48, NDM, KPC, IMP.
Minimum Test Capacity: 10 tests/kit, supporting single-sample testing for on-demand detection.
User-Friendly: Extraction-free—bacterial suspension can be directly loaded.
Quality Control: Includes built-in controls to monitor reaction validity.
Handling Time: <1 minute (sample preparation).
Instrument Run Time: <1 hour.
Performance Data：
The test accurately identifies both single and multidrug resistance genes, demonstrating consistent results without nonspecific amplification.
 Positive for the blaKPC gene |  Validation of VIM gene repeatability |
 Positive for both blaKPC and blaNDM genes |  Validation of NDM gene repeatability |
VIM gene reproducibility reference standard | ||||
Sample size | CT value | Mean | Standard Deviation | Coefficient of Variation |
1 | 35.55 | 34.91 | 3.98E-01 | 1.14% |
2 | 34.38 | |||
3 | 34.61 | |||
4 | 35.17 | |||
5 | 34.93 | |||
6 | 35.36 | |||
7 | 35.19 | |||
8 | 34.52 | |||
9 | 34.81 | |||
10 | 34.54 | |||
NDM Gene Repeatability Reference Material | ||||
Sample size | CT value | Mean | Standard Deviation | Coefficient of Variation |
1 | 29.58 | 29.78 | 5.3023E-01 | 1.78% |
2 | 30.58 | |||
3 | 30.34 | |||
4 | 30.14 | |||
5 | 29.90 | |||
6 | 30.21 | |||
7 | 29.04 | |||
8 | 29.23 | |||
9 | 29.22 | |||
10 | 29.57 | |||
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